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Self-assembled, thermosensitive PCL-g-P(NIPAAm-co-HEMA) micelles for drug delivery

机译:用于药物递送的自组装热敏PCL-g-P(NIPAAm-co-HEMA)胶束

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摘要

A novel thermosensitive amphiphilic copolymer (PCL-g-P(NIPAAm-co-HEMA)) comprised of hydrophobic PCL segments and hydrophilic P(NIPAAm-co-HEMA) segments was designed and synthesized. The structure of the copolymer was characterized by FT-IR, H-1 NMR and GPC analysis. The copolymer may self-assemble into micelles in water and the resulting micelles demonstrated temperature sensitivity with a lower critical solution temperature (LCST) of 33 degrees C. The critical micellar concentration (CMC) obtained from surface tension measurements and the fluorescence method was around 30 mg center dot L-1. Transmission electron microscopy (TEM) showed that the micelles exhibit a nanospheric morphology within a narrow size range of 150-160 nm. A cytotoxicity study showed that the PCL-g-P(NIPAAm-co-HEMA) copolymer exhibits good biocom- patibility. The controlled drug release of the resulting micelles was investigated and it was found that micelles loaded with prednisone acetate showed improved drug release behavior due to the special micellar structure.
机译:设计合成了一种由疏水性PCL链段和亲水性P(NIPAAm-co-HEMA)链段组成的新型热敏两亲性共聚物(PCL-G-P(NIPAAm-co-HEMA))。通过FT-IR、H-1 NMR和GPC分析对共聚物的结构进行了表征。共聚物可以在水中自组装成胶束,所得胶束在33°C的较低临界溶液温度(LCST)下表现出温度敏感性。通过表面张力测量和荧光法获得的临界胶束浓度 (CMC) 约为 30 mg 中心点 L-1。透射电子显微镜(TEM)表明,胶束在150-160 nm的窄尺寸范围内表现出纳米球形貌。细胞毒性研究表明,PCL-g-P(NIPAAm-co-HEMA)共聚物表现出良好的生物相容性。研究了所得胶束的受控药物释放,发现负载醋酸泼尼松的胶束由于特殊的胶束结构而表现出改善的药物释放行为。

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