Comparative evaluation of diatrizoate meglumine and iopromide for non-selective intra-arterial digital subtraction angiography of kidneys in dogs.

摘要

This experimental study was conducted in dogs for comparative evaluation of the renal vasculature and safety with ionic- diatrizoate meglumine and non-ionic (LOCM)- iopromide using intra-arterial digital subtraction angiography. 17 mongrel dogs of either sex (age: 1-7 years and wt: 8-26 kg) allotted to two groups. Non-selective intra-arterial digital subtraction angiography (DSA) of kidneys was carried out using diatrizoate meglumine 4 (Group I, n=12, 4 males and 8 females) and iopromide (Group II, n=5, 3 males and 2 females). Overnight fasted dogs were weighed, medial aspect of the femoral triangle was prepared for aseptic angiography and pre-angiography urine samples were collected. After premedication with acepromazine HCI6 0.05 mg/kg b.wt. i.m. dogs were transported 15 km to Urological Hospital for angiography studies. In the present study, there was no significant difference in radiographic image quality observed in animals of different age and sex, and most of the animals were free from preexisting renal failure as was evident from pre-angiography plasma creatinine values. The transient diarrhoea observed in one animal of the ionic group resolved within 6 hr. Based on the assessment of blood and urine parameters studied, the renal tolerability of both the contrast media can be graded equal and both contrast media inflicted almost non-significant alterations in the renal function parameters. However, diatrizoate showed acute, transient alterations immediately after the angiography, while iopromide induced alterations were less acute but lasted longer.