Correlation between Fasting Plasma Glucose in First Trimester of Pregnancy and Glucose Challenge Test in Later Months of Pregnancy as A Screening Test for Gestational Diabetes Mellitus

摘要

Objective : To find out whether fasting plasma glucose values measured in first trimester (within 10 weeks) of pregnancy has any correlation with glucose challenge test values done in later month pregnancy as a screening test for gestational diabetes mellitus. Design : Prospective study. Sample : Total 200 pregnant women attending GOPD, NRS MCH, during a period of May 2011 to April 2012. Method : All pregnant women attending for the first antenatal visit, after taking proper history universal screening was done with fasting plasma glucosef FPG). It was measured 8-10 hrs of overnight fasting. Only those women with FPG <126 mg/dl were selected for the study. They were followed as per routine procedure. Each woman was underwent 50 gm one hour glucose challenge test (GCT) at 24-28 wks of gestation. Those with GCT> 140 mg/dl were underwent 100 gm 3 hr oral glucose tolerance test(OGTT). Women who had a positive OGTT according to the criteria laid down by Carpenter and Coustan were labelled as having GDM. FPG and GCT values were compared using Chi Square test to evaluate the obtained data statistically with p<0.05 considered as significant. Result : Incidence of GDM was 4%.There was no correlation between FPG and GCT values for detecting GDM. Conclusion : Statistical analysis does not show any correlation between fasting plasma glucose and glucose challenge test values. So FPG in early months of Pregnancy should not be used as a screening test for GDM.