Pharmacokinetic and Pharmacodynamic Comparison of Two Pedylated interferon alpha-2 Formulations in Healthy Male Volunteers

Jalendra Prasad

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Pharmacokinetic and Pharmacodynamic Comparison of Two Pedylated interferon alpha-2 Formulations in Healthy Male Volunteers

机译：两种Pedylated干扰素α-2制剂在健康男性志愿者中的药代动力学和药效学比较

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Interferon (IFN) alpha conjugation to polyethylene glycol (PEG) results in a better phramacokinetic profile and efficacy. The aim of this study was to compare the pharamacokinetic, pharmacodynamic and selfety properties of a new, locally developed, 40 k Da PEG-IFN alpha-2b preparation with a reference, Commercially available PEG-IFN alpha- 2a in healthy male volunteers.

机译：干扰素（IFN）α与聚乙二醇（PEG）缀合可产生更好的促动动力学特征和功效。这项研究的目的是比较健康男性志愿者中局部开发的新的40 k Da PEG-IFNα-2b制剂与参比的市售PEG-IFNα-2a的药物动力学，药效学和自理特性。

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《Indian medical journal》 |2012年第6期|共1页
作者
Jalendra Prasad;
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正文语种 eng
中图分类医药、卫生;
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1. Pharmacokinetic and Pharmacodynamic Comparison of Two Pedylated interferon alpha-2 Formulations in Healthy Male Volunteers [J] . Jalendra Prasad Indian medical journal . 2012,第6期

机译：两种Pedylated干扰素α-2制剂在健康男性志愿者中的药代动力学和药效学比较
2. Pharmacokinetic and Pharmacodynamic Comparison of Two Recombinant Human Erythropoietin Formulations, PDA10 and Eprex, in Healthy Korean Male Volunteers: A Randomized, Double-Blinded, Single-Dose, Two-Period Crossover Study [J] . Oh MinKyung, Yoon Jaeseung, Cho Doo-Yeoun Clinical drug investigation . 2015,第10期

机译：两种重组人促红细胞生成素制剂PDA10和Eprex在健康的韩国男性志愿者中的药代动力学和药效学比较：一项随机，双盲，单剂量，两期交叉研究
3. Pharmacokinetic and pharmacodynamic comparison of two recombinant human erythropoietin formulations after single subcutaneous administration: an open-label, sequence-randomized, two-treatment crossover study in healthy Korean male volunteers. [J] . Kim TE, Kim KP, Kim BH, Clinical therapeutics . 2010,第11期

机译：单次皮下给药后两种重组人促红细胞生成素制剂的药代动力学和药效学比较：在健康的韩国男性志愿者中进行的开放标签，序列随机，两次治疗交叉研究。
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Propafenone pharmacokinetics: GLC-ECD analysis; metabolic induction by phenobarbital in nonsmoking and smoking healthy volunteers; protein binding; pharmacodynamics in patients [D] . Chan, Grace Lap-Yu 1989

机译：普罗帕酮药代动力学：GLC-ECD分析；非吸烟和吸烟健康志愿者的苯巴比妥诱导代谢；蛋白质结合；患者的药效学
6. Pharmacokinetic and pharmacodynamic comparison of two pegylated interferon alpha-2 formulations in healthy male volunteers: a randomized crossover double-blind study [O] . Idrian García-García, Carlos A González-Delgado, Carmen M Valenzuela-Silva, 2010

机译：两种聚乙二醇化干扰素α-2制剂在健康男性志愿者中的药代动力学和药效学比较：一项随机交叉双盲研究
7. Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: A randomized, crossover, double-blind study [O] . Idrian Garcia-Garcia, Carlos A Gonzalez-Delgado, Carmen M Valenzuela-Silva, 2010

机译：两种“聚乙二醇化”干扰素α-2制剂在健康男性志愿者中的药代动力学和药效学比较：一项随机，交叉，双盲研究

Pharmacokinetic and Pharmacodynamic Comparison of Two Pedylated interferon alpha-2 Formulations in Healthy Male Volunteers

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