SYNTHESIS OF SOME ETHYL 2-[3-ARYL-5-METHYL-4-OXO-3,4-DIHYDRO THIENO [2,3-d] PYRIMIDIN-2-YLOXY] ACETATES AND THEIR ANTIMICROBIAL ACTIVITY

摘要

Some new ethyl 2-[3-aryl-5-methyl-4-oxo-3,4-dihydro thieno [2,3-d] pyrimidin-2-yloxy] acetates (3a-e) were synthesized by a convenient method involving reaction of ethyl 2-amino-4-methylthiophene-3 carboxylate with aryl isocyanates followed by insitu cyclization in aq sodium hydroxide. All the compounds synthesized were characterized on the basis of their IR,~1H NMR and mass spectral data and screened for their antimicrobial activity.