ULTRASOUND AND MICROWAVE ASSISTED SYNTHESIS OF 2-(5(4-(4-ARYL)-1-PHENYL-1 H-PYRAZOL-3-YL)-4,5-DIHYDRO-1-PHENYL-1H-PYRAZOLE-3-YL)-4- SUBSTITUTED PHENOLS AND THEIR BIOLOGICAL ACTIVITY

摘要

2-(5-(4-(4-aryl)-1 -phenyl-1 H-pyrazol-3-yl)-4,5-dihydro-1 -phenyl-1 H-pyrazole-3-yl)-4-substituted phenols (lla-j) have been synthesized by the Michael addition of (E)-(2-hydroxy-5-substituted phenyl)-3-(4-(4-aryl)-1-phenyl-1/-/-pyrazol-3-yl) prop-2-en-1-ones (la-j) with phenylhydrazine under ultrasound and microwave irradiation in good yields. All the synthesized compounds (lla-j) were characterized by lR, ~1H & ~(13)C NMR and Mass spectral data and screened for their antibacterial activity.