SYNTHESIS AND ANTITUMOR ACTIVITY OF 4'-ARYL/ALKYL-2'-D ALDOSUGAR DISUSTITUTED BIS-BENZIMIDAZOLES

摘要

4'-Aryl/alkyl-2"-D-aldosugar disubstituted bis-benzimidazoles (4) were synthesized from 2-mercapto benzimidazole and 2-methyl amino benzimidazole in the presence of formaldehyde and hydrochloric acid.All newly synthesized compounds were characterized on the basis of spectral analysis and elemental data and screened for in-vivo antitumor activity,most of them showed significant activity.