GREEN SYNTHESIS OF 1-[3-(3-METHOXYPHENYL) [1,8] NAPHTHYRIDIN-2-YL]-3-(2-OXO-2H-3-CHROMENYL)-1H-4-PYRAZOLECARBALDEHYDES UNDER MICROWAVE IRRADIATION USING SOLID SUPPORT AND THEIR ANTIBACTERIAL ACTIVITY

摘要

A simple and efficient method is described for the synthesis of 1-[3-(3-methoxyphenyl) [1,8] naphthyridin-2-yl]-3-(2-oxo-2H-3-chromenyl)-.1H-4-pyrazolecarbaldehydes 4 by the reaction of 3-{1-[2-(3-(3-methoxyphenyl) [1,8] naphthyridin-2-yl] hydrazono} ethyl)-2H-2-chromenones (hydrazones) 3 with POCl3-DMF/SiO2 under microwave irradiation. The structures of the compounds 3 and 4 were confirmed by their spectroscopic (IR, H-1 NMR and MS) and analytical data. Compounds 4 have been screened for their antibacterial activity.