SOLVENT-FREE MICROWAVE ASSISTED SYNTHESIS OF 1-{6-BENZOYL-3-[(E)-2-(ARYL)-1-ETHENYL]-5-METHYLFURO [3',2': 4,5] BENZO [b] FURAN-2-YL}-1-ETHANONES AND THEIR ANTIBACTERIAL ACTIVITY

摘要

A series of 1-{6-benzoyl-3-[(E)-2-(aryl)-1-ethenyl]-5-methyl furo [3',2';4,5] benzo [b] furan-2-yl}-1-ethanones (3a-f) were synthesized by reacting (E)-1-(2-benzoyl-6-hydroxy-3-methylbenzo [b]furan-5-yl)-3-aryl-2-propen-1-ones (2a-f)with 2-chloroacetone in the presence of anhyd K2CO3 under solvent-free microwave irradiation. All the synthesized compounds were characterized by means of their IR, ~1H NMR, ~(13)C NMR, mass and elemental analysis. All the compounds were screened for their antibacterial activity.