SYNTHESIS OF 5-(2-METHOXY-1,8-NAPHTHYRIDIN-3-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE AND 1-(2-METHOXY-1,8-NAPHTHYRIDIN-3-ACETYL)-4-ARYLTHIOSEMICARBAZIDES

摘要

2-Methoxy-3-cyano-1,8-naphthyridine (1) undergoes hydrolysis to form 2-methoxy-1,8-naphthyridine-3-carboxylic acid (2). This compound was transformed to carboxylate and then converted to 2-methoxy-1,8-naphthyridine-3-carbohydrazide (4). The hydrazide (4) is cyclised to from 5-(2-methoxy-1,8-naphthyridin-3-acetyl)-1,3,4-oxadiazole-2(3H}-thione (5). 1-(2-methoxy-1,8-naphthyridin-3-acetyl)-4-arylthiosemicarbazides (6a-m) are obtained by the reaction of 4 and aromatic thioisocyanates.