SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLINES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS

摘要

A series of pyrazolines (2a-j) have been synthesized and evaluated for their antimicrobial and antiinflammatory activities. The structures of the synthesized compounds have been confirmed on the basis of physical and spectral data. Compounds 2b, 2c, 2e and 2g have shown moderate antibacterial activity. None of the synthesized compounds showed antifungal activity. Compounds 2b and 2c exhibited significant antiinflammatory activity.