SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF s-TRIAZOLO [3,4-b] [1,3,4]THIADIAZOLES, s-TRIAZOLO [3,4-b] [1,3,4] THIADIAZINES AND s-TRIAZOLO[3', 4':2, 3]-THIADIAZINO[5,6-b] QUINOXALINE

摘要

The condensation of 3-n-butyl-4-amino-5-mercapto-s-triazole 1 with chloroacetic acid, a-haloketones, benzoin, 2,3-dichloro-quinoxaline, carbon disulphide, aromatic carboxylic acids, and aromatic carboxaldehydes furnished in one step, the cyclic products, 3-n-butyl 7H-s-triazolo [3,4-6] [1,3,4] thiadiazin-6 (5H)-one 2,6-aryl-3-n-butyl-7H-s-triazolo [3,4-5] [1,3,4] thiadiazines 3,3-n-butyl-6,7-diphenyl-5H-s-triazolo [3,4-6] [1,3,4] thiadiazine 4, 3-n-butyl-5H-s-triazolo [3',4':2,3] [1,3,4] thiadiazino [5,6-6] quinoxaline 5, 3-n-butyl-s-triazolo [3,4-b] [1,3,4] thiadiazole-6 (5H)-thione 6, 3-n-butyl-6-aryl-s-triazolo [3,4-6] [1,3,4]-thiadiazoles 7 and 6-aryi-5,6-dihydro-3-n-butyl-s-triazolo [3,4-6] [1,3,4] thiadiazoles 8 respectively. The compounds have been characterized on the basis of elemental analysis and spectral data. The antibacterial and antifungal activity of some of the compounds have also been evaluated.