SOLVENT FREE MICROWAVE ASSISTED SYNTHESIS OF SUBSTITUTED 1-(3-((E)-2-(3-(ARYL)-1 -PHENYL-1H-PYRAZOL-4-YL) VINYL)-BENZOFURAN-2-YL) ETHANONES

摘要

Substituted 1 -(2-hydroxy phenyl)-3-[3-(4-aryl)-1 -phenyl-1H-pyrazol-4-yl}-propenones (la-h) have efficiently been synthesized by the condensation of 3-aryl-1-phenyl-pyrazole-4-carbaldehydes with 2-hydroxy acetophenones using basic alumina under solvent free microwave irradiation. Compounds (la-h) were reacted with chloroacetone in the presence of ignited dry potassium carbonate under solvent free microwave irradiation and also conventional heating to afford substituted 1-(3-((E)-2-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl) vinyl) benzofuran-2-yl)- ethanones (Lla-h). All the compounds synthesized have been characterized by IR, ~1H NMR and ~(13)C NMR and mass spectral analysis.