Protein Partners of alpha-Synuclein in Health and Disease

摘要

alpha-synuclein is normally situated in the nerve terminal but it accumulates and aggregates in axons and cell bodies in synucleinopathies such as Parkinson's disease. The conformational changes occurring during alpha-synucleins aggregation process affects its interactions with other proteins and its subcellular localization. This review focuses on interaction partners of alpha-synuclein within different compartments of the cell with a focus on those preferentially binding aggregated alpha-synuclein. The aggregation state of alpha-synuclein also affects its catabolism and we hypothesize impaired macroautophagy is involved neuronal excretion of alpha-synuclein species responsible for the prion-like spreading of alpha-synuclein pathology.