Leukocytosis after lithium and clozapine combination therapy.

摘要

Lithium has been successfully used as an augmentation strategy in patients with a partial response to clozapine and to prevent clozapine-associ-ated neutropenia. Lithium is well known to produce a reversible increase in white blood cell (WBC) counts of approximately 2.0 X 10~9/L, whereas clozapine may less commonly result in transient leukocytosis. We report here on 2 patients treated with both lithium and clozapine who experienced reversible leukocytosis, with WBC counts more than 3 times greater than that described in the literature.