ABSTRACTAn investigation has been made into whether charcoal hemoperfusion stimulates a hyperplastic response in the liver of the normal rat. Animals underwent hemoperfusion over Norit RBX1 (Strathclyde, Glasgow, U. K.) charcoal granules using a technique which allowed perfusion in the unrestrained and conscious state. Controls consisted of animals subjected to perfusion through empty columns and animals cannulated only. Body weight, liver weight, function, and DNA synthesis were recorded at various times after completion of perfusion and control procedures. The results indicated that charcoal hemoperfusion did not stimulate a hyperplastic response in the liver of the normal rat following perfusion, and did not produce marked changes in body weight, liver weight, and function.
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机译：摘要已经研究了木炭血液灌流是否刺激正常大鼠肝脏的增生反应。动物在Norit RBX1（Strathclyde，Glasgow，U.K.）木炭颗粒上进行血液灌流，使用一种允许在无限制和有意识状态下灌注的技术。对照组包括通过空柱进行灌注的动物和仅插管的动物。在完成灌注和对照程序后的不同时间记录体重、肝脏重量、功能和 DNA 合成。结果表明，木炭血液灌流在灌注后未刺激正常大鼠肝脏增生反应，且未产生体重、肝重和功能的明显变化。
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