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Animal Models of Autoimmune Neuropathy

机译:自身免疫性神经病的动物模型

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摘要

The peripheral nervous system (PNS) comprises the cranial nerves, the spinal nerves with their roots and rami, dorsal root ganglia neurons, the peripheral nerves, and peripheral components of the autonomic nervous system. Cell-mediated or antibody-mediated immune attack on the PNS results in distinct clinical syndromes, which are classified based on the tempo of illness, PNS component(s) involved, and the culprit antigen(s) identified. Insights into the pathogenesis of autoimmune neuropathy have beenprovided by ex vivo immunologic studies, biopsy materials, electrophysiologic studies, and experimental models. This review article summarizes earlier seminal observations and highlights the recent progress in our understanding of immunopathogenesis ofautoimmune neuropathies based on data from animal models.
机译:周围神经系统(PNS)包括颅神经,具有根和根的脊神经,背根神经节神经元,周围神经和植物神经系统的周围组件。对PNS的细胞介导的或抗体介导的免疫攻击导致不同的临床综合征,根据疾病的发作速度,所涉及的PNS成分和所识别的罪魁祸首抗原将其分类。体外免疫学研究,活检材料,电生理学研究和实验模型已经提供了对自身免疫性神经病发病机理的见解。这篇综述文章总结了较早的开创性观察结果,并根据动物模型数据突出了我们对自身免疫性神经病的免疫发病机制的了解的最新进展。

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