BamHI andSacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people

摘要

In this paper, we extend the study of the IGHG gene RFLPs in black African persons and in some other individuals characterized by a Negroid admixture. We demonstrate a polymorphism that is much more important in black Africans, that in Caucasoids, mainly for the IGHG3 and G1 genes, the most 5′ members of the IGHG multigene family. These genes encode for the IgG3 and IgG1 subclasses, which are of crucial biological importanc