Survival curves for biological cells irradiated with gamma rays (and other low LET radiations) cannot be properly interpreted without examining the implications of these interpretations for high LET radiations. The theory of RBE demands that the RBE of any high LET radiation field is at most one when the probability for cell killing as a function of the absorbed dose of gamma rays is linear or sublinear, for homogeneous samples whose radiosensitivity parameters are not altered during the irradiation. A contrary experimental finding strongly suggests that the experimental sample is heterogeneous. Violation of this constraint is not unusual where the survival curve found with low LET radiations has a well defined initial negative slope.
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机译:如果不研究这些解释对高 LET 辐射的影响,就无法正确解释用伽马射线(和其他低 LET 辐射)照射的生物细胞的存活曲线。RBE理论要求,当细胞杀伤概率与伽马射线吸收剂量的函数关系为线性或亚线性时,任何高LET辐射场的RBE最多为1,对于在辐照过程中放射敏感性参数不改变的均质样品。相反的实验结果强烈表明实验样本是异质的。当低LET辐射的生存曲线具有明确定义的初始负斜率时,违反此限制的情况并不罕见。
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