EGG ALBUMIN MATRIX MICROSPHERES INCORPORATED WITH SOLID DISPERSION OF NIMESULIDE IN HPMC IN PURSUIT OF FORMULATING EXTENDED RELEASE DOSAGE FORM

摘要

In pursuit of achieving a slow, controlled and complete release of the drug, solid dispersions of nimesulide in HPMG were prepared first. X- ray diffraction studies, IR spectral analysis were included in the analytical studies. The formulation was incorporated with egg albumin spheres and microencapsulated by ethyl cellulose as coating material. Different core:coat ratios were used. The drug release from these microspheres was found to depend on the core:coat ratio. Pharmacological studies also have been performed and reported.