NANOPARTICLES IN DRUG TARGETING - A REVIEW

摘要

The use of nanotechnology in in vivo drug targeting is a rapidly expanding field. The emphasis of this review is on this use of nanotechnology as well as the biological aspects that enable targeting of these platforms to injured and diseased tissues as well as cells. The principles of passive and active targeting of nanosized carriers to inflamed and damaged tissues with increased vascular leakiness, overexpression of specific epitopes and cellular uptake of these nanoscale systems are discussed. This review also focuses on the various approaches to drug targeting and also patenting associated with nanomedicine. Also various case studies and success story of the first nanoparticulate drug combination approved by the FDA are included herein. Taken together, this relatively new and exciting data indicates that the future of nanomedicine is indeed promising and going to set a new trend in the pharmaceutical world.