EVALUATION OF TRIBULUS TERRESTRIS MUCILAGE AS BINDER IN TABLET FORMULATIONS

摘要

The aim of this study is to develop an economic and effective natural excipient that can be used as an alternative in formulation of tablets. Tribulus terrestris (Zygophyllaceae) is a herbaceous weed native throughout India and mucilage is derived from the freshly dried and coarsely powdered leaves. Phytochemical and physiochemical characteristics of mucilage were studied. Mucilage was used in 5 different concentrations (10,15, 20, 25, and 30% w/V). Metoprolol tartrate was used as model drug for formulation. The DSC and FTIR of drug and mucilage indicate no chemical interaction. The properties were compared with guar gum (GRAS excipient). The granules were prepared by wet granulation process and evaluated. Tablets were prepared and evaluated for disintegration, dissolution and content uniformity and was subjected to stability studies as per ICH guidelines. It was concluded that lower concentration of mucilage can be used as binder. The higher concentration shows sustained release and can be considered as alternative release retardant.