Important progress has been performed during the ten past years, in the direct resolution (without derivatization) of enantiomers by column liquid chromatography. Generally chiral packings proceeding from natural or synthetic optically active polymers are used. Complete resolutions of hole families of chiral solutes is obtained in systems involving a steric locking interaction (charge transfer between aromatic substituents, crown ether cavity, crowded complexes with metal ions). For analytical purposes an other proraising way is the use of a classical packing and a chiral mobile phase.
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