ANTIDIABETIC ACTIVITY OF ROOT OF SIDA ACUTA LINN. IN NORMOGLYCEMIC AND ALLOXAN INDUCED DIABETIC RATS

摘要

The present study was undertaken to evaluate the antihyperglycemic activity of root of Sida acuta. The plant extract was found with low toxicity (LD_(50) >3g/kg). The aqueous extract of Sida acuta at the dose levels of 200 and 400 mg/kg b. wt. produced a significant decrease in fasting blood glucose (FBG) level by 62.04 and 70.66 %, respectively with respect to initial FBG level after 15 days treatment. In the oral glucose tolerance test, this extract at the dose levels of 100, 200, and 400 mg/kg decreased glycemia at 60 min and the effect persisted unit 120 min (p<0.05) after glucose loading, which showed impaired glucose tolerance. The elevated level of SGPT, SGOT and ALP in the diabetic controlled group reflected the significant alternation of liver function by alloxan induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal with this extract. For all the estimated parameters the results of the extract treated groups were restored to the near normal level, there by indicating good antihyperglycemic activity of the aqueous extract of Sida acuta.