PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS AND ANTIDIABETIC ACTIVITY OF CLERODENDRUM PHLOMIDIS (VERBANACEAE) LEAVES

摘要

The petroleum ether, chloroform, ethanol and aqueous extracts of Clerodendrum phlomidis Linn, dry leaves were screened for various phytoconstituents. Phytochemical analysis revealed the presence of secondary metabolites like phytosterols, triterpenoids, saponins, alkaloids, tannins and carbohydrates as major phytoconstituents. Phytochemical analysis plays an important role in the standardization of crude herbal drugs. The antidiabetic effect of ethanol extract of the leaves of Clerodendrum phlomidis Linn, was investigated in alloxan induced diabetic rats. The blood glucose levels were measured at 8th, 16thand 24th day after the treatment. The ethanol extract of Clerodendrum phlomidis Linn. (250 mg/kg) reduced the blood glucose level in alloxan induced diabetic rats from 303.3 +- 6.7 to 136.7 +- 4.9 on 24th day of intraperitonial administration ( i.p) of the test extract ( P < 0.001 ). The antidiabetic activity of Clerodendrum phlomidis Linn, was compared with reference drug insulin.