Neuropathogenesis of Central Nervous System HIV infection

摘要

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are a common and devastating complication of HIV infection, affecting up to 47 of HIV-seropositive individuals in the combination antiretroviral (cART) era.1 Because HAND independently predicts non-central nervous system (CNS) morbidity and overall HIV mortality,2 there is an urgent need to better understand these disorders to develop therapeutic approaches. However, HIV neuropathogenesis, HAND, and its related neuropathology, HIV-encephalitis (HIVE), are complex and incompletely understood. This article describes the current understanding of the basic virology and neuropathogenesis of HIV that contribute to HAND and HIVE.