Synthesis and beta-adrenergic blocking activity of naphthyloxypropylamines

摘要

A series of 1-isopropylamino-3-(3'-substituted-2'-naphthyloxy)-2-propanols have been synthesized and their structures have been confirmed by spectral analysis.All the derivatives have shown beta-adrenergic blocking effect when tested on perfused frog heart.Compound 4e exhibited 100% blockade of adrenaline response.