Novel and thermally stable ionic liquid (TBA acetate) for domino reaction: Synthesis of spirooxindoles via new mechanistic way

摘要

A simple, efficient and environmentally benign method for the one-pot, three component synthesis of spirooxindoles under task-specific novel ionic liquid Tetrabutylammonium acetate (TBA acetate) mediated and catalyzed conditions is described involving isatin 1, malononitrile 2 and cycli-1,3-diketone 3a-d / pyrazolone 3e compounds. This method is of significant value due to the eco-friendly and basic nature of ionic liquid there by eliminating usage of separate base catalyst to drive the reaction forward.