Iodine/AcCl-catalyzed Prins-Ritter reaction: Synthesis of 4-amido tetrahydropyrans

摘要

Homoallylic alcohols, carbonyl compounds and nitriles undergo a smooth tandem Prins-Ritter type cyclization in the presence of iodine/AcCl at room temperature to produce 4-acetamido tetrahydropyrans in high yields with all m-selectivity.