Zinc chloride-catalyzed one-pot synthesis of 3-(2-(3-mcthyl-4,5-dihydro-furo(2,3-c)-pyrazol-1 -yl)thiazol-4-yl)-chromen-2-ones via a three component reaction

摘要

A simple and convenient procedure for the synthesis of 3-[2-(3-mcthyl-4,5-dihydro-furo[2,3-c]pyrazol-1-yl)-thiazol-4-yl]-chro-men-2-oncs 4a-f is described through anhydrous zinc chloride-catalyzed one pot condensation of 3-(2-bromoacetyl)coumarin, thiosemicarbazide and 2-acetylbutyrolactone in good yields. The title compounds 4a-f are also synthesized via an alternative procedure.