Glucosamine Hydrochloride Functionalized Water-Soluble Conjugated Polyfluorene: Synthesis, Characterization, and Interactions with DNA

摘要

Novel glucosamine hydrochloride functionalized water-soluble conjugated polyfluorene was easily synthesized through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. The water-solubility and biocompatibility of the polymer were improved after grarting glucosamine hydrochloride to the side chains of the conjugated polymer. As a fluorescent model system of chitosan, its interaction with single-stranded DNA was studied by spectrofluorometric titration.