I-123 metaiodobenzylguanidine imaging in non-insulin-dependent diabetic patients with normal myocardial perfusion scans: new insights into their increased cardiac morbidity and mortality rates.

摘要

Diabetes is a well-recognized risk factor for cardiovascular morbidity and death. According to the National Cholesterol Education Program III guidelines, diabetes is regarded as a coronary artery disease (CAD) risk equivalent with a predicted 10-year cardiovascular mortality rate of greater than 20.1 It is also known, however, that diabetic patients can be further risk-stratified on the basis of evidence of end-organ damage manifesting as retinop-athy, microalbuminuria, silent ischemia, and neuropathy.2 Cardiovascular autonomic neuropathy (CAN) is believed to be a serious complication of diabetes, with a prevalence of 20 to 35 in patients with non-insulin-dependent diabetes mellitus (NIDDM) according to the various study criteria.