Synthesis and bioactivity study of 2,5-bismercapto-1,3,4-thiadiazole eterocyclic derivatives

摘要

A series of acylhydrazone compounds 3a-i and acylthiosemi-carbazides 4a-h containing thiadiazole rings have been synthesized conveniently in high yields.Some heterocyclic derivatives 5 are prepared by the method of dehydration of compounds 4.Structure of all these compounds have been confirmed by elemental analysis,IR,1H and 13C NMR.The bioassay result indicates that some compounds have relatively low antibacterial activity and other compounds have bioactivity for improving plant growth.