Synthesis of 4-thiazolidinone and 2-azetidinone derivatives of 2-trifluoromethyl-1,8-naphthyridine as antibacterial agents

摘要

Ethyl 2-trifluoromethyl-1,8-naphthyridine-3-carboxylate 3 has been synthesized by the condensation of 2-aminonicotinaldehyde 1 with ethyl trifluoroacetoacetate 2 and subjected to hydrazinolysis with refluxing hydrazine hydrate to give 2-trifluoromethyl-1,8-naphthyridine-3-carboxylic acid hydrazide 4.