Synthesis and pharmacological evaluation of some novel 5-aryl-6-arylamino-1-phenylpyrazolo[3,4-d]pyrimidin-4(5H)-ones as analgesic and anti-inflammatory agents

摘要

A weries of novel title compounds 4a-o has been synthesized through two different synthetic routes.While the first involves the condensation of pyrazole o-aminoester 1 with aryl isothiocyanates 2,the second involves cyclocondensation of alkyl isothiourea ethers of sym-diarylthioureas 5 with 1.