An efficient synthesis of lactarochromal from 6-amino-2,2-dimethylchroman-4-one

摘要

Lactarochromal 1, a metabolite of Lactarius deliciosus, has been synthesised starting from 6-amino-2,2-dimethylchroman-4-one 3, which in turn, is prepared from paracetamol via the known intermediates. The amino compound 3 is then converted to the iodo compound 4, followed by formylation of the latter using N-formylpiperidine to provide, efficiently, the natural product 1 in good yield.