Synthesis of novel thiazolo[5,4-d]pyrimidines

摘要

2-Methylsulphanyl-5-aminothiazole-4-carboxamide 1 has been used as a convenient precursor for the synthesis of new thiazolo[4.5-e][1,2,4-triazolo][4,3-c]pyrimidines 5 and the corresponding tetrazolo analogue 7. A mesoionic isomer 8 seems to exist along with 7. Interesting heteroarylthiazolo pyrimidine motifs have also been prepared via suitably substituted thiazolo[5,4-d]pyrimidines.