Synthesis of new succinate-dihydrotestosterone-dihydropyrimidine conjugate

摘要

A new steroid-dihydropyrimidine derivative has been synthesized. The route involves preparation of dihydrotesto-sterone-dihydropyrimidine derivative 4 using dihydrotestosterone 1, benzaldheyde 2, and thiourea 3 in presence of hydrochloric acid, followed by esterification of 4 with succinic acid 5 which results in the formation of succinate-dihydrotestosterone-dihydropyrimidine conjugate 6.