Microwave-assisted synthesis and biological activity of 3-alkyl /aryl-6-(l-chloro-3,4-dihydronaphth-2-yl)-5,6-dihydro-s-triazolo [3,4-b] [1,3,4] thiadiazoles

摘要

3-Alkyl/aryl-6-(l-chloro-3,4-dihydronaphth-2-yl)-5,6-dihydro-s-triazolo[3,4-b)][l,3,4]thiadiazoles 3 have been synthesised by the condensation of 5-alkyl/aryl-4-amino-3-mercapto-l,2,4-triazoles 2 with l-chloro-2-formyl-3,4-dihydronaphthalene 1 in presence of catalytic quantity of p-TsOH under microwave irradiation.Rate enhancement and improvement in yields,characteristics of synthesis under microwave irradiation,have been observed.The compounds synthesised have been characterised and screened for their antibacterial,antifungal,antiinflammatory and antioxidant activity.