Copper-catalyzed substitution reactions of acylal with organomanganese reagents

摘要

A mild method for the copper-catalyzed substitution of aldehyde acylals with organomanganese reagents is reported.This operationally simple C-C bond-forming protocol uses different Cu(I) catalysts.Acylal from trans-cinnamaldehyde furnishes conjugated addition product when reacted with alkyl and aryl organomanganese reagents in presence of 10 mol % of Cu(NCMe)2 (PPh3)2[BF4] and 2 equivalent of Me3Si-Cl as an accelerator.This reagent can be efficiently used in the substitution of one acetate group of aromatic acylal to form esters in high yield.