Lithium chloride as an efficient catalyst for Friedlander synthesis of 1,8-naphthyridines via the use of microwave irradiation and pestle/mortar

摘要

An efficient,practical and eco-friendly method of preparation of 1,8-naphthyridines 3 has been reported by Friedlander condensation between 2-aminonicotinaldehyde 1 and active methylene compounds 2 in the presence of lithium chloride in combination with microwave irradiation and also with a pestle and mortar.