Condensed bridgehead nitrogen heterocyclic systems:Microwave assisted synthesis and bioactivity of s-triazolo[3,4-b][1,3,4]thiadiazoles, s-triazolo[3,4-b][1,3,4]thiadiazines and s-triazolo [3',4':2,3]-thiadiazino[5,6-b]quinoxaline

摘要

N-[3-(4-Amino-5-mercapto-4H-[1,2,3]triazol-3-yl)-4,5,6,7-tetrahydrobenzo[b] thiophen-2-yl]acetamide 1 on condensation with chloroacetic acid,alpha-haloketone and benzoin furnishes [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives 2,3 and 4 respectively,while condensation with 2,3-dichloroquinoxaline,carbon disulphide,aromatic carboxylic acid and aromatic carboxaldehydes yield the cyclic products,[1,2,4] triazolo[3,4-b][1,3,4]thiadiazole derivatives 5,6,7,8 respectively.The compounds have been characterized on the basis of elemental analysis and spectral data.The antibacterial,antifungal and antitubercular activities of the compounds have also been evaluated.