Hansch analysis of anticancer activities of C_2-modified paclitaxel analogs against human ovarian carcinoma 1A9, human colon carcinoma HCT116 and human burkitt lymphoma CA46 cell lines

摘要

Anticancer activities, recently reported by Kingston et al, of paclitaxel and its thirty analogs, having substitution(s) on the phenyl ring of 2-benzoyloxy moiety, against human ovarian carcinoma 1A9, human colon carcinoma HCT116 and human burkitt lymphoma CA46 cell lines have been subjected to QSAR analyses by extrathermodynamic approach of Hansch.