An RCM based approach to (+-)-herbertene-1,14-diol and (+-)-tochuinyl acetates

摘要

A sequence comprising of Johnson's ortho ester Claisen rearrangement,alkylation and RCM reactions has been developed for the synthesis of cyclopentenes containing vicinal quaternary carbon atoms.The versatility of the sequence has been demonstrated by the efficient total synthesis of sesquiterpenes tochuinyl acetates and herbertene-1,14-diol.