Synthesis of novel alpha-arylproplonic acids and their derivatives

Arava VR; Siripalli UBR; Dubey PK

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Synthesis of novel alpha-arylproplonic acids and their derivatives

机译：新型α-芳基丙酸及其衍生物的合成

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摘要

A series of 2-(6H-betizo[c]chromen-3-yl)propionic acids have been synthesized and evaluated for COX-2 inhibitor activity.

机译：已经合成了一系列2-（6H-苯并[c] chromen-3-yl）丙酸，并评估了其COX-2抑制剂的活性。

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《Indian Journal of Chemistry, Section B. Organic Including Medicinal》 |2007年第8期|共4页
作者
Arava VR; Siripalli UBR; Dubey PK;
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正文语种 eng
中图分类化学;
关键词
alpha-arylpropionic acids; COX-2 inhibitor activity; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LEUKOTRIENES; INHIBITION;

机译：α-芳基丙酸;COX-2抑制剂活性;非甾体类抗炎药;白三烯;抑制作用;

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1. Synthesis of novel alpha-arylproplonic acids and their derivatives [J] . Arava VR, Siripalli UBR, Dubey PK Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2007,第8期

机译：新型α-芳基丙酸及其衍生物的合成
2. Synthesis of chloromethyl ketone derivatives of fatty acids. Their use as specific inhibitors of acetoacetyl-coenzyme A thiolase, cholesterol biosynthesis and fatty acid synthesis [J] . D P Bloxham, R A Chalkley, S J Coghlin, The biochemical journal . 1978,第3期

机译：脂肪酸的氯甲基酮衍生物的合成。它们用作乙酰乙酰辅酶A硫解酶，胆固醇生物合成和脂肪酸合成的特异性抑制剂
3. Synthesis of 2-Amino-5-(2-aryl-2-oxoethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic Acids Derivatives by Recyclization of 5-Arylfuran-2,3-diones under the Action of Cyanoacetic Acid Derivatives [J] . Ivanov D. V., Igidov N. M., Rubtsov A. E. Russian Journal of Organic Chemistry . 2016,第5期

机译：5-芳基呋喃-2,3-二酮在该作用下的环化反应合成2-氨基-5-（2-芳基-2-氧代亚乙基）-4-氧代-1H-4,5-二氢呋喃-3-羧酸衍生物氰乙酸衍生物
4. Michael Addition Reactions between Nucleophilic GlycineEquivalents and Acrylic Acid Derivatives as a Practicaland Generalized Approach to the Asymmetric Synthesisof II-Substituted-a-Amino Acids [C] . Vadim A. Soloshonok, Hisanori Ueki, Trevor K. Ellis ACS symposium asymmetric synthesis and application of α-amino acids . 2009

机译：亲核糖糖糖尿剂与丙烯酸衍生物之间的迈克尔添加反应作为不对称合成的不对称 - A-氨基酸的不对称方法的普遍化方法
5. I. SPIRO ASYMMETRIC INDUCTION: SYNTHESIS OF OPTICALLY PURE ALPHA-HYDROXY- AND ALPHA,BETA-DIHYDROXY ACID DERIVATIVES. II. OXIDATIVE ELECTROLYSIS OF GAMMA-KETAL CYCLOHEXANECARBOXYLIC ACIDS: TOTAL SYNTHESIS OF MALYNGOLIDE [D] . CHENG, MINN-CHANG 1987

机译：I.螺线不对称诱导：光学纯的α-羟基和α，β-二羟基乙酸衍生物的合成。二。 γ-羟基环己烷羧酸的氧化电解：丙二醛的合成
6. Synthesis of chloromethyl ketone derivatives of fatty acids. Their use as specific inhibitors of acetoacetyl-coenzyme A thiolase cholesterol biosynthesis and fatty acid synthesis. [O] . D P Bloxham, R A Chalkley, S J Coghlin, 1978

机译：脂肪酸的氯甲基酮衍生物的合成。它们用作乙酰乙酰辅酶A硫解酶胆固醇生物合成和脂肪酸合成的特异性抑制剂。
7. Studies on Ampicillin and Amoxicillin Derivatives. III. Synthesis of 6-2-(Pyrido2, 3-d pyrimidin-6-yl) methylamino-2-phenylacetamido penicillanic Acid Derivatives, 6-2-(4-Pyrimidinylamino)-2-phenylacetamido penicillanic Acid Derivatives and-cephalosporanic Acid Derivatives [O] . SHINSAKU MISHIO, TOHRU HIROSE, JUNJI NAKANO, 1987

机译：氨苄青霉素和阿莫西林衍生物的研究。 III。 6- 2 - 2 - （吡啶2,3-D嘧啶-6-基）甲基氨基 -2-苯基乙酰氨基青霉酸衍生物，6- 2-（4-嘧啶氨基）-2-苯基乙酰胺青霉酸酸衍生物和 - 孢菌酸衍生物
8. Stereoselective synthesis of optically active aspartic acid from derivatives of fumaric acid and maleic acid [R] . Harada, K., Matsumoto, K. 1966

机译：从富马酸和马来酸的衍生物立体选择性合成光学活性的天冬氨酸

Synthesis of novel alpha-arylproplonic acids and their derivatives

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