Clay-catalyzed high-speed synthesis of thiadiazepine in one-pot

摘要

Microwave assisted clay-catalyzed solid state integrated chemical process which enables the consumption of toxic intermediates and their isolation from environment, reduce reaction time, cost and complex isolation procedures enhances yields are effective for realizing a green chemical process in library syntheses of bio-active compounds. This is described here in the synthesis of thiadiazepine. Antifungal screening results on Fusarium oxysporum and Penicillium citrinum show that most of the synthesized compounds display promising antifungal activity, comparable with griseofulvin and dithane M-45 as standards.