Synthesis and biological activities of prenylated tyrosine derivatives,the metabolites of Pithomyces ellis

摘要

2-[4-(2E)-3-Methylbut-2-enyloxy)phenyl]ethan-1-ol 3 and 3-[4-(2E)-3-methyIbut-2-enyloxy)phenyl]-2-(acetylamino)propanoic acid 8 have been synthesized from 4-hydroxyphenylacetic acid 1,L-tyrosine 4,respectively,with an overall yield of 55% and 37%.The spectral data of synthetic 3 and 8 are in good agreement with those of natural 3 and 8,respectively.These synthetic 3 and 8 show significant brine shrimp lethality,but weak antioxidant and antibacterial activities.