Studies on spiroheterocycles part-I:Installation of biologically active heterocyclic nuclei into spiro compounds derived from cyclohexanone and diphenyl thiobarbituric acid

摘要

Diarylidene ketones 1a-c,prepared by the condensation of acetone with different appropriate aldehydes,on Michael addition with 1,3-diphenyl-thiobarbituric acids afford the desired spiro compounds 2a-c.The diarylidene derivatives 3a-1 undergo cyclisation with hydrazine,phenyl hydrazine,hydroxylamine,urea and guanidine carbonate to furnish pyrazole 4a-1,phenyl pyrazole 5a-1,isoxazole 6a-1,pyrimidine 7a-1,and aminopyrimidine 8a-1 compounds,respectively.The structures of all the compounds have been confirmed on the basis of their analytical,IR,NMR and Mass spectral data.The antimicrobial activities of some of the compounds have also been reported.