Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)-phenyl]formamide:Formal synthesis of formoterol

摘要

Nitration,benzylation followed by bromination of 4- hydroxy-acetophenone is described to obtain nitrobenzyloxyphenacyl bromide derivative 3.Sodiumborohydride reduction of 3 gives rise to the diol 6.Reaction of 6 with Ph_3P/I_2/imidazole yields sty-rene derivative 7.Compound 7 on selective reduction of the nitro group followed by N-formylation and epoxidation affords the key,intermediate N-[2-benzyloxy-5-(2-oxiranyl)phenyl]formamide 4.