Condensation of reactive phenols with aromatic 1,2-diketones:A single step protocol for synthesis of benzo-fused gamma-lactones

摘要

The condensation of certain reactive phenols with aromatic 1,2-diketones has been investigated under acid / Lewis acid catalysis.The reaction has provided in acceptable yields a single major product,identified as benzo-fused gamma-lactone.1,2-Aryl migration via the intermediacy of a cyclic zwitterionic intermediate is proposed to account for the formation of the gamma-lactone products.